Atletico Madrid and Barcelona have been forced into changes from their last league games with injuries on both sides. Diego Simeone is missing Jan Oblak, Tiago, Augusto Fernandez and Jose Gimenez while Luis Enrique must make do without Lucas Digne, Andres Iniesta and Sergio Busquets.
With another 90 minutes to come next Tuesday, it remains to be seen how the two managers approach the game. Simeone will surely look to prevent the visitors from scoring at the Calderon while Enrique might think an away goal could make things slightly less complicated for his side at the Camp Nou next week.
The hosts have opted for a four man midfield with Juanfran playing on the right and will look to link up with Sime Vrsaljko, who keeps his place at right-back, it would appear. Kevin Gameiro has been dropped. Diego Simeone seems to be choosing midfield stability over attacking firepower at the Calderon.
Starting XI: Moya, Vrsaljko, Godin, Savic, Filipe Luis, Gabi, Koke, Juanfran, Saul, Carrasco, Griezmann
Luis Enrique has opted to pick Javier Mascherano and it looks like the Argentine will play as a defensive midfielder with Ivan Rakitic and Andre Gomes slightly in front of him in midfield. Jordi Alba replaces the injured Lucas Digne, who went off in the first half of Barcelona's drawn game against Real Betis at the weekend.
Starting XI: Cillessen, Piqué, Rakitic, Suárez, Messi, Neymar, Mascherano, Alba, S.Roberto, André Gomes, Umtiti