Gareth Bale returns from a calf injury to start for Real Madrid in El Clásico, while Paco Alcácer forms the third part of Barcelona's attacking trident in the absence of Neymar.
Real Madrid: team news
Bale has missed Real Madrid's last two matches as a result of a calf injury sustained in the Champions League quarter-final victory over Bayern Munich.
Zinedine Zidane indicated that Bale would be included in his match-day squad, but it is mildly-surprising that he will start this crucial La Liga clash. His inclusion represents a swift return from injury, and Isco has filled in excellently in those last two matches.
Otherwise, Real Madrid line up as expected in a 4-3-3 formation.
Real Madrid XI: Navas, Carvajal, Ramos, Nacho, Ronaldo, Kroos, Benzema, Bale, Marcelo, Casemiro, Modric.
Barcelona: team news
Luis Enrique's team selection is less controversial. The only change-from-the-norm for Barcelona is the enforced inclusion of Paco Alcácer, as a result of Neymar's suspension.
Barcelona has tried to overturn the Brazilian's suspension, imposed as the result of a red card in a defeat to Málaga, but were unable to do so.
It appears that Barcelona will also line up in a 4-3-3 formation, despite having utilised a 3-4-3 in recent weeks.
Barcelona XI: Ter Stegen, Roberto, Piqué, Umtiti, Alba, Busquets, Rakitic, Iniesta, Alcacer, Messi, Suárez.