Dani Carvajal has returned to the Real Madrid squad for the derby against Atlético, the Spain defender having been passed fit after suffering a viral pericardium infection that has kept him on the sidelines for the past six weeks.
Gareth Bale and Keylor Navas also miss out as they continue their recoveries from injury while Achraf Hakimi, Jesús Vallejo and Marcos Llorente.
Mateo Kovacic, although back in full training after a knee injury, has also been left out as he continues to regain fitness.
Real Madrid squad for Atlético
Goalkeepers: Kiko Casilla, Moha.
Defenders: Dani Carvajal, Raphael Varane, Sergio Ramos, Nacho, Marcelo, Theo Hernández.
Midfielders: Casemiro, Toni Kroos, Luka Modric, Dani Ceballos, Isco, Marco Asensio.
Forwards: Lucas Vázquez, Cristiano Ronaldo, Karim Benzema, Borja Mayoral.