Paco Alcácer will miss el Clásico on 23 December after picking up a muscular injury in his left leg during Barcelona's comfortable victory over relegation-threatened Deportivo.
Alcácer injured in early stages
The striker hobbled off after 21 minutes and was replaced by Aleix Vidal. It comes as a blow for both Alcácer and his coach, Ernesto Valverde.
After an inauspicious debut season at Barcelona following his transfer from Valencia, Alcácer has become a useful option in attack, scoring three goals in his last six matches in all competitions.
Barcelona confirm extent of injury
Barcelona have released an official statement confirming that Alcácer will be out for three weeks, and will therefore miss the upcoming trip to the Bernabéu.
He will aim to return for the LaLiga match against Levante on 7 January.