Sergio Ramos returns for injury against Leganés on Wednesday night and started for Las Blancos on his retuen. Isco along with Benzema also start as Zinedine Zidane's side look to seal their place in the semi-final of the Copa del Rey after their 1-0 win at Butarque last week.
The central defender was absent from the Clásico with an injury but is back to bolster Zidane's defensive options and Karim Benzema, who hurt himself during the game against Barcelona and has not started a game in 2018 leads the line after coming on at the Santiago Bernabeu during Madrid's 7-1 win over Deportivo la Coruña at the weekend. He has only played five full games this season and has not scored since November, which he will try to fix in the second leg at the Bernabéu on Wednesday night.
Isco, who was on the bench against Depor but did not come on, also starts. The creative midfielder was an undisputed starter during the earlier parts of the season but has slipped down the pecking order with the return of Gareth Bale. He will play in place of Dani Ceballos, who is suffering from a knee injury. Isco has only started two of the last eight games and didn't see a second of action against Barcelona.