Messi wasn't on the pitch for Argentina against Spain as he failed to overcome his hamstring niggles, with the Barcelona star watching from the VIP section of the Wanda Metropolitano alongside Lanzini.
But Messi's face fell as he watched Spain go on a scoring spree against his countrymen, and when Isco scored Spain's sixth (the Real Madrid man's hat-trick) Leo had had enough, standing up and walking out of the stands.
Busquets watching Spain destroy Argentina
Sergio Busquets was also in the VIP secion, alongside Fernando Hierro. He wasn't in the squad due to injury, but there's no doubt he's a starter for Lopetegui as one of Spain's key players.
Other big footballing names in the stands were former Spain coach Vicente del Bosque and Atlético Madrid manager Diego Simeone.