A ruling by the highest court in Switzerland means a doping ban handed to the Peru star will continue, ruling him out of action until April 2019.
Peru and Internacional striker Paolo Guerrero has seen his latest appeal against a drugs ban rejected by the Swiss Federal Tribunal (BGER).
The BGER confirmed the decision on Monday, meaning Guerrero's ban will stand and he will not be available to play until April 2019.
Guerrero was banned for one year by FIFA after he tested positive for benzoylecgonine, a metabolite of cocaine, after Peru's World Cup qualifier against Argentina in October 2017.
Swiss Federal Tribunal rejects request to temporarily lift Paolo Guerrero's doping ban to allow him to play for @SCInternacional whilst his case is subject to appeal: https://t.co/PE70RvqsQn pic.twitter.com/yA0nRcjvZY— Sports Integrity SII (@Sport_Integrity) 1 October 2018
An appeal initially saw the suspension cut in half but the World Anti-Doping Agency successfully argued to the Court of Arbitration for Sport that the ban was insufficient and it was extended to 14 months.
However, Guerrero was cleared to captain Peru at the 2018 World Cup after a temporary lifting of his ban was approved.
Guerrero signed a three-year contract at Internacional in August after his deal with Flamengo expired, but he is yet to play for the club due to suspension.
Internacional are level on points with Palmeiras at the top of the Campeonato Brasileiro after 27 matches.