Cardinals suffer crushing setback with veteran RB sidelined indefinitely
The Arizona Cardinals lost to the San Francisco 49ers on Sunday, but they had even worse news surrounding running back James Conner.
On Sunday, the Arizona Cardinals suffered a devastating loss to the San Francisco 49ers, 16-15. But even more devastating still is the fact that their starting running back, James Conner, was carted off the field with an ankle injury.
Prayers up for James Conner 🙏 pic.twitter.com/KAdzPExqZ5
— FOX Sports: NFL (@NFLonFOX) September 21, 2025
What injury does James Conner have and when will he return for the Cardinals?
In the third quarter of the game, Conner was hit both high and low at the same time and as he was being tackled, his leg bent awkwardly, leaving teammates visibly shaken. He was carted off the field and designated with an ankle injury and did not return to the game.
WAY too many injuries today...Cardinals RB James Conner is being carted off the field after being tackled very awkwardly.
— Arye Pulli (@AryePulliNFL) September 21, 2025
The broadcast did not show the replay-- very telling of the severity of the injury. pic.twitter.com/Qpi26CUrrX
It’s now been confirmed that he will undergo surgery and is out for the season. A veteran leader and key piece of Arizona’s offense, Conner’s absence leaves major questions for the Cardinals’ backfield. Before leaving the game, he had nine carries for 22 yards.
Cardinals RB James Conner did in fact suffer a season-ending injury to his right ankle that will require surgery, per source. The injury is considered “severe”, even if the team does not yet know the full extent of the damage. pic.twitter.com/IMktQeYBoz
— Adam Schefter (@AdamSchefter) September 22, 2025
Second-year rusher Trey Benson has shown flashes and may be asked to take on a bigger role, while Emari Demercado could see more snaps. On Sunday, Benson became the top rusher and has 21 carries for 125 yards through three games now.
With the Cardinals thin at running back, the team must quickly figure out how to adjust after the emotional and costly defeat.
Related stories
Get your game on! Whether you’re into NFL touchdowns, NBA buzzer-beaters, world-class soccer goals, or MLB home runs, our app has it all.
Dive into live coverage, expert insights, breaking news, exclusive videos, and more – plus, stay updated on the latest in current affairs and entertainment. Download now for all-access coverage, right at your fingertips – anytime, anywhere.
Complete your personal details to comment