49ers - Vikings betting trends: Pick, odds, point spread and over/under prediction | NFL week 2

The Minnesota Vikings and San Francisco 49ers are coming off dominant Week 1 victories, setting the stage for a highly anticipated clash this Sunday in Minnesota. Despite playing on the road, the 49ers enter the game as six-point favorites. However, history may be on the Vikings’ side, as they have won their last seven home matchups against San Francisco, including a 22-7 victory last season as a seven-point underdog.

49ers - Vikings: point spread

Kickoff is scheduled for 1 p.m. ET, and the total points for the game are 45.5. San Francisco, a consistent NFC contender under head coach Kyle Shanahan, hasn’t won in Minnesota since 1992, a stretch that spans 32 years. While some may dismiss these historic trends, the Vikings’ recent head-to-head success over the 49ers, particularly at home, is noteworthy. In those seven games, Minnesota is also 6-1 against the spread (ATS).

Both teams were impressive in their season openers. The Vikings dismantled the New York Giants 28-6 as one-point favorites, while the 49ers earned a 32-19 win at home against the New York Jets, covering the 4.5-point spread. Both defenses held their opponents to under 300 yards, showcasing their defensive prowess.

49ers - Vikings: Pick, odds and trends

One key factor heading into Sunday’s matchup is the potential fatigue factor for San Francisco. The 49ers played on Monday night, giving them one less day of rest than the Vikings, who last played Sunday. Additionally, San Francisco will travel across time zones to play a well-rested Minnesota team in their home dome. Though modern NFL teams are used to adjusting for these variables, it could be a challenge for Shanahan’s squad.

Further complicating matters for the 49ers is their history of struggling in dome stadiums under Shanahan. Since taking over as head coach, San Francisco is 5-7 straight up and just 3-9 ATS when playing in domes. The 49ers have also found the NFC Norbe particularly difficult, going 2-2 straight up and 0-4 ATS against the division since 2022.

There’s a notable betting trend that works in Minnesota’s favor as well. When an NFL home faces a non-division opponent and comes off a road victory in which they covered the spread as a favorite, they tend to perform exceptionally well. Minnesota fits this description after covering as a one-point favorite at the Giants. NFL teams in this situation have gone 13-0 ATS and 10-3 straight up since 1993.

Considering all these factors, the Vikings appear to be in a favorable position heading into this match. While coming off a solid win in San Francisco, they face a challenging road test with the potential for fatigue, a tough, tricky environment, and recent struggles against NFC North teams.