49ers vs Seahawks betting trends: Pick, odds, point spread and over/under prediction | NFL week 6

The San Francisco 49ers are 3.5-point favorites heading into their Thursday night showdown against the Seattle Seahawks, continuing their recent dominance in this divisional rivalry. San Francisco has won five straight games against Seattle, going 4-1 against the spread (ATS) during that span and securing each victory by double digits.

This matchup has been one-sided in recent history, but Seattle is known for bouncing back at home after losses.

Recent results and what to expect from the 49ers and the Seahawks

The Seahawks are coming off a tough 29-20 loss to the New York Giants at home. However, Seattle has only lost back-to-back home games twice since 2011—and on both occasions, the losses came at the hands of the 49ers. Despite the recent history, the Seahawks have a respectable overall record at home and will be looking to avoid repeating that unfortunate trend on Thursday night.

Notably, Seattle enters this game as a home underdog; although the Seahawks hold a winning 3-2 record, they are underdogs by more than a field goal against a San Francisco team with a losing record. This situation has immediately triggered betting angles, especially when considering Thursday night division games. Historically, Thursday night home underdogs within the division—like Seattle—with a win percentage of .400 or better are 10-2 against the spread since 2012 when facing a team with a worse record.

Additionally, away favorites with a losing record, like the 49ers, have struggled in these division matchups. Since 2011, such teams are 1-23-1 against the spread when facing a division opponent with a winning record. These stats highlight San Francisco’s challenge as they enter this Thursday night clash.

Despite these trends favoring Seattle, some experts remain confident in San Francisco. The line speaks volumes regarding the betting line favoring the 49ers by more than a field goal. While Seattle has been resilient at home, San Francisco’s recent dominance in the series and the decisiveness of their victories have many believing the 49ers will cover the spread once again.