Christian McCaffrey (RB – SF)
- Dealing with calf injury but ramping up his activity level and expected to be ready Week 1. (8/28)
Tyreek Hill (WR – MIA)
- Dealing with a minor hand injury that is being treated cautiously but should be ready for Week 1 (8/28)
Jahmyr Gibbs (RB – DET)
- Returned to practice on 8/25 but no report as to t he extent of his participation. Still expected to be available Week 1.
Puka Nacua (WR – LAR)
- Returned to practice 8/26 but yet to be full participant.
Davante Adams (WR – LV)
- Dealing with a minor injury with no new info since 8/20
Jaylen Waddle (WR – MIA)
- Practicing with non-contact jersey but on track to play Week 1 (8/26)
Sam LaPorta (TE – DET)
- Returned to practice on 8/26. Still worth monitoring his hamstring injury.
Christian Kirk (WR – JAC)
- Dealing with calf injury but returning to practice the last week of August (8/28)
Mark Andrews (TE – BAL)
- Involved in car accident with no injuries reported but has not practiced since (8/28)
Jaylen Warren (RB – PIT)
- Dealing with hamstring injury but expected to be ready for Week 1 (8/28)
DeAndre Hopkins (WR – TEN)
- Dealing with Knee injury. Reports saying he could be ready for Week 1. (8/28)
David Njoku (TE – CLE)
- Dealing with undisclosed injury but expected to participate in practice the last week of August
Brock Bowers (TE – LV)
- Dealing with a sore foot. Should be ready for Week 1. (8/28)
Jordan Addison (WR – MIN)
- Dealing with ankle injury – no timetable for return (8/28)
Marquise Brown (WR – KC)
- Dealing with shoulder injury and remains uncertain for Week 1. (8/28)
Dallas Goedert (TE – PHI)
- Dealing with an oblique injury status for Week 1 uncertain (8/28)
Justin Herbert (QB – LAC)
- Recovering from foot injury but should be ready for Week 1 (8/28)
Jonathon Brooks (RB – CAR)
- Will begin season on NFI and miss at least the first four games (8/28)
Tyler Lockett (WR – SEA)
- Dealing with leg issue and remains sidelined at practice. Status for Week 1 is in question. (8/28)
Nick Chubb (RB – CLE)
- Will begin season on PUP list and miss at least the first four weeks. (8/28)
Zach Charbonnet (RB – SEA)
- Dealing with undisclosed tightness but expected to be ready for Week 1. (8/28)
Curtis Samuel (WR – BUF)
- Dealing with toe injury but optimistic he will be ready for Week 1. (8/28)
T.J. Hockenson (TE – MIN)
- Recovering from ACL/MCL tear; beginning camp on PUP list (7/27) – Expected to miss anywhere from three to seven weeks of regular season (8/9)
Brandin Cooks (WR – DAL)
- Dealing with knee injury. Unsure of status for Week 1. (8/28)
Josh Downs (WR – IND)
- Dealing with high ankle sprain. Status uncertain for Week 1. (8/28)
Hunter Henry (TE – NE)
- Remains sidelined with undisclosed injury. Unknown status for Week 1. (8/28)
MarShawn Lloyd (RB – GB)
- Dealing with hamstring injury but avoided starting season on IR and should be ready sometime in September. (8/28)
Noah Fant (TE – SEA)
- Dealing with foot injury but believed will be ready for Week 1. (8/28)
Kendre Miller (RB – NO)
- Placed on IR and will miss at least the first four games. (8/28)
Ricky Pearsall (WR – SF)
- Dealing with shoulder injury and questionable for Week 1. (8/28)
Tucker Kraft (TE – GB)
- Dealing with pectoral injury but expected to be ready for Week 1. (8/28)