Umtiti and Sissoko step in for Rami and Kanté against Iceland
Umtiti, who's already signed for Barcelona, and the Newcastle midfielder replace the two suspended Frenchmen against Iceland, bothe teams playing for a sem-final berth.
France coach Didier Deschamps handed Samuel Umtiti his international debut as the Euro 2016 hosts made two enforced changes for Sunday's quarter-final against Iceland in Paris.
Umtiti, 22, who is set to join Barcelona from Lyon later this month replaces the suspended Adil Rami in central defence alongside Laurent Koscielny.
Moussa Sissoko comes in for N'Golo Kante, who is also serving a one-match ban, on the right side of midfield with Deschamps opting for a 4-2-3-1 at the Stade de France.
Iceland became the first nation to use the same starting XI for their first five matches at the European Championship as joint-coaches Lars Lagerback and Heimir Hallgrimsson kept faith with the side that beat England 2-1 last Monday.
Starting line-ups for the Euro 2016 quarter-final between France and Iceland at Stade de France in Paris on Sunday (1900 GMT kick-off):
France (4-2-3-1)
Hugo Lloris (capt); Bacary Sagna, Samuel Umtiti, Laurent Koscielny, Patrice Evra; Blaise Matuidi, Paul Pogba; Moussa Sissoko, Dimitri Payet, Antoine Griezmann; Olivier Giroud
Coach: Didier Deschamps (FRA)
Iceland (4-4-2)
Hannes Halldorsson; Birkir Saevarsson, Ragnar Sigurdsson, Kari Arnason, Ari Skulason; Johann Gudmundsson, Aron Gunnarsson (capt), Gylfi Sigurdsson, Birkir Bjarnason; Jon Dadi Bodvarsson, Kolbeinn Sigthorsson
Coaches: Lars Lagerback (SWE) and Heimir Hallgrimsson (ISL)
Referee: Bjorn Kuipers (NED)