Kompany in for City, while Zouma enters the fray
Chelsea bring in Kurt Zouma, with Azpilicueta shifting to the flank. For Pep's chaps, Delph and Kompany replace Sterling and Otamendi.
Follow Matt's minute-by-minute coverage of Chelsea v Manchester City.
Victor Moses is the only absentee for Antonio Conte this evening. The Nigerian has enjoyed a right-wing-back renaissance this season, but he is suffering with a toe injury. . Eden Hazard (calf) and David Luiz (knee) will both play despite slight discomfort.
Pep Guardiola will be without Ilkay Gungogan, Gabriel Jesus, and Bacary Sagna. Jesus Navas played in an unfamiliar right-back role against Arsenal on Sunday, and may continue there at Stamford Bridge.
Chelsea
The Italian coach adopted a 'three at the back' system after a watershed defeat to Arsenal on the 24th of September. From then, until the last match against Crystal Palace, Conte fielded the same back six: Courtois; Moses, Azpilicueta, Cahill, Luiz, Alonso.
With Moses unavailable, Zouma will enter the fray at centre half, with Azpilicueta moving to right wing back.
Chelsea XI: Courtois, Zouma, David Luiz, Cahill (c), Azpilicueta, Kante, Fabregas, Alonso, Pedro, Diego Costa, Hazard.
Manchester City
It has felt like a season of adaptation at The Etihad, as Pep Guardiola seeks to impose his methodology on the squad he inherited last summer.
Fabian Delph starts for Manchester City, while Sterling drops to the bench. At the heart of the defence, club captain Vincent Kompany takes the place of Nicolas Otamendi.
Manchester City XI: Caballero, Clichy, Stones, Kompany (c), Fernandinho, Delph, Sane, Silva, De Bruyne, Navas, Aguero.