Isco scored a hat-trick at the Wanda Metropolitano as Spain turned in an insatiable performance to comdemn Argentina to their worst defeat since 2009.
Lionel Messi watched from the stands as Diego Costa opened the scoring after 12 minutes. Isco doubled the hosts' lead shortly before the half-hour mark, but Nicolás Otamendi reduced the deficit soon after with a header that David De Gea should have managed to save.
After the break, Spain improved and Argentina capitulated in equal measure. Isco and Thiago scored a quickfire double at the start of the second period. A further 20 minutes passed before Spain struck again, this time Aspas and Isco scoring in rapid succession.
The match crumbled in to a series of niggly fouls as the final whistle drew closer. Messi did not watch until the end, instead deciding to slope inside with minutes remaining. Julen Lopetegui has tuned his side at the perfect time. The World Cup is less than three months away and Spain look like ominous contenders. For Jorge Sampaoli, a torrid evening in Madrid posed more questions than answers.