Tony Adams suffered defeat in his first match as Granada head coach as the Andalusians lost 3-0 to Celta Vigo at Nuevo Los Cármenes in LaLiga on Sunday.
Ex-Arsenal and England captain Adams was appointed until the end of the season on Monday after Lucas Alcaraz's sacking as boss of the relegation strugglers.
Alcaraz was fired in the wake of a 3-1 home loss to Valencia that left the side in 19th in Primera División and on a run of five defeats in six league games.
Granada lose out to three-goal Celta
But Adams was unable to spark an immediate upturn in Granada's fortunes against Celta, who won with goals by Jozabed, Marcelo Díaz and Claudio Beauvue.
In the 23rd minute of the week 32 clash, on-loan Fulham winger Jozabed dinked a fine finish past goalkeeper Guillermo Ochoa to put the visitors ahead.
And the Galicians sealed victory in the closing stages of the second 45 when a 73rd-minute Díaz free-kick was quickly followed by a close-range Beauvue strike.
Celta's win came despite coach Eduardo Berizzo fielding a second-string side to keep players fresh for Thursday's Europa League quarter-final clash with Genk.
Away clash with Sevilla up next for Adams' team
The result means that Granada remain seven points adrift of safety, with six more games left to play - starting with a tough trip to Sevilla on Friday night.
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