Barcelona's defence of the LaLiga title will begin at home against Deportivo Alaves on August 19 but the newly released fixture list sees the champions have to wait until October to face their most likely challengers.
Real Madrid travel to Camp Nou on October 28 for the first Clasico clash of the 2018-19 season, with the return at Santiago Bernabeu on March 3 in 2019.
Barca beat their rivals 3-0 away from home last season, with the return fixture ending in a 2-2 draw after the hosts had Sergi Roberto sent off.
Just two weeks after the visit of Los Blancos, Ernesto Valverde's side travel to the capital to face Atletico Madrid, who will visit Camp Nou on April 7 next year.
They finish their league schedule with a trip to Eibar, though the precise fixture dates and times remain subject to change.