The only question here is whether or not Buffalo will cover that 14.5-point line. Well, I think they will. Bills 33-17 Jaguars
UPSET
Las Vegas (-3) at New York Giants
First Jon Gruden and now Henry Ruggs. Derek Carr's world is slowly falling apart. Giants 27-24 Raiders
TWO MINUTE DRILL
New York Jets at Indianapolis (-10.5)
Another upset from the Jets? Another Carson Wentz fiasco? Colts 31-21 Jets
Minnesota at Baltimore (-5.5)
If your defense allows 120 rushing yards per game, you're in trouble in Baltimore. Ravens 29-20 Vikings
New England (-4) at Carolina
Cleveland at Cincinnati (-3)
After the fiasco against the Jets, Cincinnati returns home to entertain a Cleveland team that has lost three of the last four. Bengals 28-24 Browns
Denver at Dallas (-10)
Dak Prescott is back and Von Miller is now a Ram. Cowboys 28-14 Broncos
Houston at Miami (-6.5)
Two teams that won in Week 1 and then lost seven in a row. It is recommended to stay away from this sh… I mean, poor show. Dolphins 19-13 Texans
Atlanta at New Orleans (-6)
With Trevor Siemian as its starting quarterback, New Orleans relies more than ever on its defense. Saints 23-19 Falcons
Los Angeles Chargers (-1.5) at Philadelphia
The Chargers' run defense is the worst in the league and Philadelphia comes into this game after racking up 236 yards at Detroit. However... Chargers 33-31 Eagles
Arizona in San Francisco (pk)
Including the 2020 season, San Francisco is 1-10 at home. Cardinals 29-20 49ers
Tennessee at Los Angeles Rams (-7.5)
Adrian Peterson makes his debut in place of the injured Derrick Henry. Los Angeles 31-21 Tennessee
Chicago at Pittsburgh (-6.5)
Justin Fields has had his moments, but the Pittsburgh defense will make him look like what he is: a rookie quarterback in the NFL. Steelers 27-17 Bears