Top-scoring Dallas goes against the shaky Chiefs, while Panthers' Newton meets his former coach

Indeed in this season of exciting results without any apparent Super Bowl favorite, Week 10 stood out for its altogether quantity of upsets.

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The defending champion Tampa Bay Buccaneers were surprised by the Washington Football Team. The Miami Dolphins upset the Baltimore Ravens, and the league-leading Arizona Cardinals fell to the Carolina Panthers.

Meanwhile, the San Francisco 49ers then beat NFC West rivals the Los Angeles Rams in Monday Night Football, and it became the first week in NFL history in which four teams had won by double-digits, having started the week at least four wins behind their opponents.

Week 11 seems no more apparent to call, and there is an abundance of intriguing matchups before even contemplating the potential for further difficulties for some favorites.

Dallas Cowboys (7-2) @ Kansas City Chiefs (6-4)

With Patrick Mahomes back on form, two of the best teams in the NFL should be set for a titanic tussle at Arrowhead Stadium on Sunday.

Mahomes, setting aside his shaky displays to that point, threw for 406 yards and five touchdowns with no interceptions against the Las Vegas Raiders last week, becoming the first quarterback in the Super Bowl era to have two games of 400-plus passing yards, five-plus TD passes and no picks in his career.

The 41-14 win represented the league-leading 10th time the Chiefs have scored 40 points in a game since the start of the 2018 season, yet they were topped by the Cowboys, whose 43-3 defeat of the Atlanta Falcons was their biggest since a 48-7 victory over Arizona in 2000.

The Cowboys have gone 5-2-1 all-time previously in games following a win of at least 40 points (including playoffs), but this was an unprecedented success. The team's 29 points in the second quarter in Week 10 were their most in a single quarter of any game in their history.

Indianapolis Colts (5-5) @ Buffalo Bills (6-3)

Neither the Chiefs nor the Cowboys can match the Bills' average winning margin of 26.3 points this year. That is the highest mark in the NFL, having been boosted by last week's 45-17 victory over the New York Jets, their NFL-leading sixth win by 15 or more points.

The Cowboys are ahead of the Bills in points per game, but Buffalo have given up the fewest points per game. The last team to lead on both offense and defense in this regard were the 2005 Colts.

The achievements of this year's Colts team have been rather more modest. Their five wins have come against teams with a combined record of 13-34 (.261).

Still, Jonathan Taylor has excelled, scoring a rushing touchdown in seven straight games – the last NFL player to reach eight was DeAngelo Williams in 2008. In fact, there is rushing talent on both sides of the ball, with the Bills last week having four different players score rushing TDs for the first time in team history.

Arizona Cardinals (8-2) @ Seattle Seahawks (3-6)

Another week, another big NFC West game. The Cardinals' form has tailed away a little since Kyler Murray's injury, but they are still unbeaten on the road and looking to start 6-0 away from home for only the second time in franchise history.

Meanwhile, the Seahawks have their starting QB back, but Russell Wilson did little to help their offense against the Green Bay Packers. He was shut out for the first time in his NFL career in his 166th start (including playoffs).

Seattle's problems on that side of the ball did not end there, though. They were held to under 100 rushing yards for a third consecutive game for the first time since the end of the 2016 season, while only twice in the 21st century have they seen such a streak extended to four games.

Whether or not the Seahawks recover this week, history suggests they are likely to be able to stick with the Cardinals. Six of the past 10 meetings between the teams have been decided by three points or fewer.

Elsewhere...

Cam Newton's Panthers face Ron Rivera's Washington, their first meeting since both left Carolina (Newton returned last week). This is the third time since 2010 a former MVP QB has faced the coach he won his award with, following Peyton Manning versus Jim Caldwell in 2015 and Tom Brady against Bill Belichick earlier this season.

The 49ers are now 4-1 when Jimmy Garoppolo's passer rating is above 100.0 this year (141.7 vs. the Rams) and 0-3 when it is not. He was helped last week by a season-high 156 rushing yards, keeping San Francisco's offense on the ball for just over 39 minutes. They should expect more of the same against the Jacksonville Jaguars, who have failed to force a turnover in six games this season.

The Cincinnati Bengals need both of their former LSU stars to rediscover some form at the Raiders. Joe Burrow has thrown an interception in five straight games, the longest active streak in the NFL, while Ja'Marr Chase – surely not helped by his QB's struggles – has fallen short of 50 receiving yards in consecutive games after making that mark in his first seven appearances.

The Detroit Lions will hope to learn from next opponents the Cleveland Browns, who have returned to contention since in 2018 becoming the first team in the Super Bowl era to end a losing streak of 10-plus games with a tie. Last week, against the Pittsburgh Steelers, the Lions became the second.