NFL Fantasy Football Week 12: who to pick for Thanksgiving

The neutral has plenty to be thankful for in this thrilling 2021 NFL season.

But all that drama, driven by a series of stunning against-the-odds upsets, can make life miserable for fantasy players, even at this celebratory time of year.

Want to maintain your cheer through another seemingly unpredictable slate of games this Thanksgiving week? Turn to Stats Perform for the below data-powered picks.

Quarterback: Jalen Hurts, Philadelphia Eagles @ New York Giants

The Eagles head into Week 12 rejuvenated, having won three of their past four games to improve to 5-6 ahead of a big NFC East matchup. Those three wins have all had one thing in common: Philadelphia have exceeded 200 yards rushing.

This run-heavy approach – with a league-high 49.6 rush percentage – wisely plays to the strengths of quarterback Hurts, who had three rushing scores last week against the New Orleans Saints as he surpassed 50 yards on the ground for the fifth straight game.

That was Hurts' 15th QB start. He ranks second through 15 QB starts since 1950 for rushing touchdowns (11 – behind Cam Newton, 14) and second through 15 QB starts since 1960 for rushing yards (890 – behind Lamar Jackson, 1,193).

The Giants – reeling from a bad defeat to the Tampa Bay Buccaneers – have given up 4.38 yards per rush play, ranking a mediocre 19th, and have not yet played any of the six best offenses in that regard. The Eagles' offense (4.99 yards per rush), led by Hurts, sits third and will be eyeing further big gains.

Running back: Joe Mixon, Cincinnati Bengals vs. Pittsburgh Steelers

Mixon is already enjoying a career year with nine rushing TDs, and the 2021 season might be about to get a whole lot better for the running back – and any fantasy players who can count on him – as the Bengals face an injury-ravaged Steelers defense.

Pittsburgh have now given up the most yards per rush play (4.76) after a tough two weeks in which their roster was hit by absences and it showed on the field. The winless Detroit Lions tallied 229 rushing yards and two TDs in their Week 10 tie, before the Los Angeles Chargers averaged 6.12 yards per rush as Austin Ekeler's two scores headlined a Week 11 win.

Mixon, who has rushing TDs in four straight games and last week ran for over 100 yards for the first time since Week 1, should get free rein against a Steelers defense that successfully disrupts the run on just 24.62 per cent of attempts.

Even if Pittsburgh can fix a problem that has persisted throughout the season and got worse of late, Mixon ranks 12th among running backs (min. 10 carries) with 3.74 yards per carry on disrupted runs.

Wide receiver: Deebo Samuel, San Francisco 49ers vs. Minnesota Vikings

A significant shift towards a run-heavy approach – the 49ers averaged 25.6 rushes per game through Week 9 but 43.0 per game since – would be an issue for most wide receivers, but Samuel is not most wide receivers.

It is his versatility that has helped accommodate a change that has potentially brought San Francisco back into contention.

Samuel caught only one pass against the Jacksonville Jaguars last week but rushed for 79 yards and a TD in the absence of injured rookie Elijah Mitchell. The previous week, with Mitchell involved against the Los Angeles Rams, Samuel had rushing and receiving scores in the same game for the first time in his career.

With the Vikings' rush defense matching the Steelers' in giving up 4.76 yards per rush, expect Samuel and the Niners to run the ball again and do it well.

Tight end: Kyle Pitts, Atlanta Falcons @ Jacksonville Jaguars

Pitts is the sixth-most targeted tight end this season (69) but has the third-most receiving yards (635), boosted massively by 100-yard games against the New York Jets and the Miami Dolphins either side of the Falcons' Week 6 bye.

The schedule slowed that momentum somewhat – Atlanta were held to three points across defeats to the Dallas Cowboys and the New England Patriots – but a trip to Jacksonville gives Pitts the opportunity to put his name up in lights once again.

The Jaguars have given up 7.20 yards per pass play in 2021, meaning this is unlikely to be the defense to keep Pitts in check. He has got open on 34.41 per cent of his 93 matchups, up on the tight end average of 18.10 per cent.

Defense: New England Patriots vs. Tennessee Titans

The Titans head into this week as the top seed in the AFC, but the Patriots may well take that spot from them over the next two weeks, hosting Tennessee before going to the Buffalo Bills in Monday Night Football.

While Mac Jones is enjoying a fine rookie year at QB, it will be New England's defense that puts them in contention, having given up only 5.07 yards per play while securing 21 total takeaways – ranking third in both regards.

And the Pats will expect to dominate the Titans, whose injury list has only grown since Derrick Henry went down. A.J. Brown is the latest offensive weapon to be unhealthy, while Julio Jones is not expected back for another two weeks.

These problems contributed to a woeful defeat to the Houston Texans last time out, when Ryan Tannehill threw four picks. Elsewhere in Week 10, New England caught four interceptions against the Falcons.