Real Madrid's Benzema needed to shoot the Sheriff
Manchester City and Real Madrid will want payback for their previous respective losses to PSG and Sheriff in the Champions League.
Manchester City boss Pep Guardiola will be looking to seal top spot in Group A of the Champions League on Wednesday with a win against Paris Saint-Germain at the Etihad Stadium, having lost the reverse fixture 2-0 in the French capital in September.
Carlo Ancelotti and Real Madrid will also be seeking revenge as they visit Sheriff after the Moldovan outfit famously won 2-1 at the Santiago Bernabeu on matchday two.
After losing their first league game of the season at the weekend, Milan must find the first win of their European campaign if they are to keep their hopes of qualification alive when they travel to Atletico Madrid.
Stats Perform picks out the key Opta facts ahead of Wednesday's Champions League action.
Manchester City v PSG: Messi aims to smite Guardiola again
Despite failing to find the net in Paris, only Bayern Munich (17) have scored more goals than Manchester City (15) in the Champions League this season. The Citizens are averaging 3.4 expected goals per game in the competition this term; since the start of 2013-14, this is the highest per-game average by a team in the group stage in a single Champions League campaign.
PSG are winless in their past three away games in the Champions League (D2 L1), and could go without an away victory in the group stage of the competition in a single season for the first time since 2004-05.
Lionel Messi, who fired home a brilliant second in the reverse game, has scored seven goals in seven Champions League appearances against City, the second-most by a player against an English club in the competition after his own haul of nine goals in six appearances against Arsenal.
Real Madrid have won both of their away games in the Champions League this season without conceding a goal (1-0 v Inter and 5-0 v Shakhtar Donetsk), while they last managed this in three consecutive away games in the competition between October 2014 and February 2015, during Carlo Ancelotti’s first spell in charge of the club.
After their famous win in Spain this season, Sheriff could become just the fourth team to win their first two meetings with Madrid in European competition, after Liverpool (1981, 2009), Galatasaray (2000, 2001) and Benfica (1962, 1965).
One rather big obstacle to stop that from happening is Karim Benzema, who has scored in each of his previous three Champions League appearances (four goals), and will be looking to do so in four in succession for the first time since 2016-17. His brace against Shakhtar last time out took him to 100 direct goal involvements in the Champions League (75 goals and 25 assists).
Atlético Madrid v Milan: Must-win for the Rossoneri
Stefano Pioli's side need a win to keep their slim hopes of qualification for the knockout stages alive, having amassed just one point from their four games, but the numbers do not bode well for the Rossoneri. Atletico Madrid have a 100 per cent record against Milan in European competition, winning all three of their meetings, which have all been in the Champions League – 1-0 away and 4-1 at home in 2013-14, and 2-1 away from home this season.
Joao Felix has been directly involved in four of Atletico's previous five goals at the Wanda Metropolitano in the Champions League, scoring three times himself and providing an assist for Antoine Griezmann against Liverpool in October.
Milan have only won one of their past 16 games against Spanish opponents in the Champions League (D6 L9), beating Barcelona 2-0 at home in the round of 16 in 2012-13. Indeed, they are winless in their previous six such games (D1 L5), suffering defeats in each of the most recent four.
Liverpool v Porto: Salah still a threat
Liverpool may have already sewn up top spot in Group B, but they will want to keep up their impressive record against Porto. The Reds are unbeaten in their nine meetings in European competition (W6 D3), with five of those games coming during Jurgen Klopp's reign (W4 D1).
Since the start of 2017-18 – Mohamed Salah's first season as a Liverpool player – the Egypt star has scored 30 goals in 47 Champions League appearances. Only four of these have been penalties, with Robert Lewandowski (33) being the only player to have netted more non-penalty goals in the competition than Salah (26) during this period.
Porto defender Pepe could make his 100th career start in the Champions League in this game. In doing so, he would become just the second Portuguese player in the history of the competition to start a century of games, after Cristiano Ronaldo.
Besiktas v Ajax
5 – Besiktas have lost all five of their meetings with Ajax across all European competitions – only against Dynamo Kyiv (six) have they suffered more defeats.
4 – Ajax are one of only four teams with a 100 per cent record through the opening four matchdays of the 2021-22 Champions League. The Amsterdam side will be looking to become only the second Dutch team to win their opening five games of a European Cup/Champions League campaign, after Feyenoord in 1971-72.
Inter v Shakhtar Donetsk
0 – The previous three meetings between Inter and Shakhtar Donetsk in the Champions League have finished goalless, with all three coming since the start of last season. There have been 66 shots recorded in these previous three games (43 by Inter and 23 by Shakhtar), without a goal being scored.
2 – Shakhtar Donetsk have only lost two of their past six away games against Italian sides in the Champions League (W2 D2), going unbeaten in the most recent two – 2-1 versus Atalanta in October 2019 and 0-0 v Inter in December 2020.
Club Brugge v Leipzig
1 – Club Brugge have only won one of their past 15 home games in the Champions League (D6 L8), with that lone victory coming against Zenit in December 2020 (3-0). This was the only game in this run in which the Belgian side managed to score more than one goal, netting just 10 across the 15 games in total.
0 – RB Leipzig are winless in their past six Champions League games, suffering five defeats in this run (D1). The Bundesliga outfit have also conceded more goals in the competition in 2021 than any other team, shipping 17 in six games this calendar year.
Sporting CP v Borussia Dortmund
3 – Only Salah (3.01), Lewandowski (4.77) and Sebastien Haller (5.51) have accumulated a higher xG tally (excluding penalties) in this season's Champions League than Sporting's Paulinho (2.96), who has scored with three of his six shots on target to date.
5 – Without Erling Haaland, who is already ruled out of this contest through injury, Dortmund have managed just five goals in four Champions League matches (1.25 on average), compared to 20 in 12 with him in the side (1.7) since his debut for the club in February 2020.