Players Player was brought on as a substitute

Pos.	Player	Team	Total
1	Brandon Vázquez Forward	FC Cincinnati	25Player was brought on as a substitute
2	Nnamdi Chinonso Offor Forward	Chicago Fire FC	23
	Andrés Ríos Forward	San Jose Earthquakes	23
	Chris Wondolowski Forward	San Jose Earthquakes	23
3	Valeri Midfielder	Portland Timbers	22
	Anderson Julio Santos Forward	Real Salt Lake	22
4	Tom Barlow Forward	New York Red Bulls	21
5	Rodney Redes Forward	Austin FC	20
6	Malte Amundsen Defender	New York City FC	19
	Julián Carranza Forward	Inter Miami CF	19
	Justin Meram Forward	Real Salt Lake	19
	Alexandru Matan Midfielder	Columbus Crew	19
	Cade Cowell Forward	San Jose Earthquakes	19
7	Tesho Akindele Forward	Orlando City SC	18
	Jhonder Cádiz Forward	Nashville SC	18
	Felipe Martins Midfielder	D.C. United	18
	Higuaín Midfielder	Inter Miami CF	18
	Kljestan Midfielder	LA Galaxy	18
	Alex Muyl Midfielder	Nashville SC	18
	Teal Bunbury Forward	New England Revolution	18
	Ryan Raposo Forward	Vancouver Whitecaps FC	18
8	Sunusi Ibrahim Forward	CF Montréal	17
	Franco Jara Forward	FC Dallas	17
	Andrés Ricaurte Midfielder	FC Dallas	17
	Daniel Musovski Forward	Los Angeles Football Club	17
	Quinn Sullivan Midfielder	Philadelphia Union	17
	Aké Loba Forward	Nashville SC	17
9	Bjorn Maars Forward	CF Montréal	16
	Silvester van der Water Forward	Orlando City SC	16
	Nicolás Mezquida Midfielder	Colorado Rapids	16
	Maikel Chang Midfielder	Real Salt Lake	16
	Jonathan Lewis Midfielder	Colorado Rapids	16
	Daniel Leyva Midfielder	Seattle Sounders FC	16
	Carlos Fierro Forward	San Jose Earthquakes	16
	Patrick Mullins Forward	Toronto FC	16
	Luke Haakenson Midfielder	Nashville SC	16
10	Benji Michel Forward	Orlando City SC	15
	Andres Jasson Midfielder	New York City FC	15
	Ariel Lassiter Forward	Houston Dynamo FC	15
	Wright-Phillips Forward	Columbus Crew	15
	Schon Forward	FC Dallas	15
11	Ahmed Hamdi Midfielder	CF Montréal	14
	Kekuta Manneh Forward	Austin FC	14
	Marvin Loría Midfielder	Portland Timbers	14
	Omir Fernandez Midfielder	New York Red Bulls	14
	Andre Shinyashiki Forward	Colorado Rapids	14
	Elliot Collier Forward	Chicago Fire FC	14
	Ricketts Forward	Vancouver Whitecaps FC	14
	Jon Gallagher Defender	Austin FC	14
	Jack McGlynn Midfielder	Philadelphia Union	14
	Fredy Montero Forward	Seattle Sounders FC	14
	Indiana Vassilev Midfielder	Inter Miami CF	14
12	Brek Shea Defender	Inter Miami CF	13
	Jaroslaw Niezgoda Forward	Portland Timbers	13
	Erick Torres Forward	Atlanta United	13
	Paxton Pomykal Midfielder	FC Dallas	13
	Zohran Ludovic Bassong Defender	CF Montréal	13
	Royer Midfielder	New York Red Bulls	13
	Paul Marie Defender	San Jose Earthquakes	13
	Jose Rodriguez Midfielder	Houston Dynamo FC	13
	Shea Salinas Midfielder	San Jose Earthquakes	13
	Sebastian Berhalter Midfielder	Austin FC	13
	Adam Saldaña Midfielder	LA Galaxy	13
	Thiago Andrade Forward	New York City FC	13
	Bobby Wood Forward	Real Salt Lake	13
	Talles Magno Forward	New York City FC	13
	George Fochive Midfielder	Portland Timbers	13
	Santiago Moreno Midfielder	Portland Timbers	13
13	Ismael Tajouri Forward	New York City FC	12
	Jay Chapman Midfielder	Inter Miami CF	12
	Darwin Ceren Midfielder	Houston Dynamo FC	12
	Jhon Espinoza Defender	Chicago Fire FC	12
	Blanco Midfielder	Portland Timbers	12
	Justin Morrow Defender	Toronto FC	12
	Ethan Zubak Forward	LA Galaxy	12
	Cameron Dunbar Forward	LA Galaxy	12
	Luka Stojanovic Midfielder	Chicago Fire FC	12
	Bryce Duke Midfielder	Los Angeles Football Club	12
	Calvin Harris Forward	FC Cincinnati	12
	Raheem Edwards Forward	Los Angeles Football Club	12
	Juan Agudelo Forward	Minnesota United FC	12
	Franuel Amaya Midfielder	New York Red Bulls	12
	Liam Fraser Midfielder	Columbus Crew	12
	Ramón Ábila Forward	D.C. United	12
14	Medunjanin Midfielder	FC Cincinnati	11
	Sergi Santos Forward	Philadelphia Union	11
	Cory Burke Forward	Philadelphia Union	11
	Scott Caldwell Midfielder	New England Revolution	11
	Mustafa Kizza Defender	CF Montréal	11
	Moor Defender	Colorado Rapids	11
	Quintero Forward	Houston Dynamo FC	11
	Joe Corona Midfielder	Houston Dynamo FC	11
	Nick DeLeon Midfielder	Toronto FC	11
	Brian Galván Midfielder	Colorado Rapids	11
	Brian Gutierrez Midfielder	Chicago Fire FC	11
	Dru Yearwood Midfielder	New York Red Bulls	11
	Thomas McNamara Midfielder	New England Revolution	11
	Ethan Finlay Midfielder	Minnesota United FC	11
	Christopher Mueller Forward	Orlando City SC	11
	Andrés Perea Midfielder	Orlando City SC	11

MLS - Liga USA

Players Player was brought on as a substitute