New coach Julen Lopetegui will face Getafe in his first LaLiga fixture in charge of Real Madrid.
Lopetegui, sacked by Spain on the eve of the World Cup after his Madrid move was announced, gets the chance to start his reign at the Santiago Bernabeu on August 19.
An away game against Girona follows, with Madrid – now minus all-time leading scorer Cristiano Ronaldo - avoid their fellow big guns in the opening weeks of the campaign.
Champions Barcelona host the first Clasico meeting of the season on October 28, with the return fixture in the Spanish capital set for March 3 next year.
The first Madrid derby sees Lopetegui's side host their neighbours at the end of September, while the Wanda Metropolitano will be the venue for the return in February.
Madrid close their campaign at home to Real Betis - scheduled for May 19 - though the precise fixture dates and times are subject to change.
Real Madrid's fixtures in full: