NFL: Chiefs bid to end Bills run, Cardinals' 100% record faces 49ers test

The Kansas City Chiefs will be aiming to bring the Buffalo Bills' winning run to an end when the two teams face off in a standout NFL Week 5 matchup.

Buffalo made it three victories in a row with a 40-0 rout of the Houston Texans last Sunday.

Week 4 was also one to remember for the Chiefs and particularly Andy Reid, who became the first coach in NFL history to win 100 games with two teams thanks to a 42-30 defeat of his former employers the Philadelphia Eagles.

As the only team with a perfect record, the Arizona Cardinals will look to make it 5-0 at the expense of the San Francisco 49ers.

Stats Perform previews the pick of the action in the next round of matches and the best of the rest.

Buffalo Bills @ Kansas City Chiefs

The Bills are sitting pretty at the top of the AFC East at 3-1, but they have lost five of their past six meetings against the Chiefs.

Buffalo will be on a revenge mission after they were beaten 38-24 by Kansas City in the AFC Championship Game last season, the largest margin of victory for the Chiefs in those five triumphs.

The Bills' thrashing of the Texans was the second time this season they have kept an opponent scoreless, having also done so against the Miami Dolphins in Week 2.

Reid's side prop up the AFC West with a 2-2 record, but their 18 touchdowns is more than any in the NFL and Josh Gordon will be hoping to add to that tally if he makes his debut.

San Francisco 49ers @ Arizona Cardinals

The Cardinals' dream start to the season continued with a 37-20 victory over the Los Angeles Rams in Week 4, taking them to 4-0 for only the second time since moving to Arizona nine years after they previously won their opening four games.

If recent history is anything to go by, there will not be much in their showdown this weekend, as four of the past five meetings between the two sides have been decided by only three points.

The 2-2 49ers travel to State Farm Stadium having come out on top in four of their previous four meetings, after losing their eight clashes beforehand.

Deebo Samuel caught a 76-yard touchdown pass in San Francisco's 28-21 loss to Seattle Seahawks in Week 4, making him the fourth 49ers wide receiver to have multiple receiving touchdowns of 75-plus yards in a single season – joining Torrey Smith, John Taylor, and Jerry Rice.

Full screen

Cleveland Browns @ Los Angeles Chargers 

The Browns and the Chargers have made promising starts to the season and both come into the game on the back of wins that took them to 3-1.

Cleveland have not beaten the Chargers on the road since back in 1991, losing five on the spin since then – a run that is tied for their third-longest active road losing streak against an opponent (lost 17 straight in Pittsburgh and six straight at New England).

The past two games mark the first time the Browns have allowed seven points or fewer back-to-back since September 10-17, 1995. They have done so in three straight games only once in franchise history (in 1976).

Nick Chubb (388) and Kareem Hunt (355) are the second pair of running backs in the last 30 years to have 350+ scrimmage yards apiece over their team's first four games of a season. The other was the Chargers' Melvin Gordon III and Austin Ekeler in 2018. 

Elsewhere

Tom Brady broke Drew Brees' NFL passing yards record in the Tampa Bay Buccaneers' win over his former team the New England Patriots in Week 4 and could inflict more misery on the Dolphins this weekend. The legendary quarterback has thrown 67 touchdowns against Miami the third-most by a player against any opponent in the Super Bowl era (Dan Marino – 72 v. the New York Jets, Brady – 70 v. the Bills). 

The Green Bay Packers head to Cincinnati to do battle with the Bengals, who they beat 27-24 in their last encounter in 2017. That snapped a three-game winning streak by the Bengals in the series. The Packers' last win in Cincinnati came in Week 3 of the 1998 season.

Urban Meyer has come under fire for his night out after the Jacksonville Jaguars suffered a fourth loss from four last week and he really needs a win when the Florida team host the Tennessee Titans. Tennessee are 7-1 versus the Jaguars since 2017.

NFC East leaders the Dallas Cowboys will go in search of a fifth consecutive home win over the New York Giants.