Scientists revive this extinct keystone species in ‘Game of Thrones’ thanks to DNA from a 13,000-year-old tooth and a 72,000-year-old skull

The Dire wolf went extinct over 13,000 years ago, and using a skull from more than 72,000 years ago, scientists at Colossal Biosciences were able to bring the species back. The company focuses on “de-extinction” through CRISPR gene editing technology. Colossal states that its mission is to “build radical new software tools and technologies to advance the science of genomics overall.”

The efforts have been applauded by the Trump administration, with Secretary of the Interior, Doug Bergum commending the advancements made, and expressed excitement about future applications.

Why the Dire Wolf?

One reason the species was chosen is due to the Game of Thrones fandom, which became acquainted with the Dire wolf through the beloved television series. The Stark family is represented by the Dire wolf, and Colossal Biosciences can leverage the species’ fame to raise awareness about their advancements in gene modification.

The scientists used DNA from the skull to edit the DNA of the modern Grey wolf, which shares 99.5 percent of its genetic makeup with the formerly extinct species. By editing the genes that differ in Grey wolves, the pups born share all the same genetic characteristics as the Dire wolves that walked the earth thousands of years ago.

The ethical questions that arise

The advancements raise ethical questions about reviving species that have been extinct for centuries, especially when hundreds of species are struggling to survive today. Additionally, the question arises of what to do with the animals born from genetic modification. It remains unknown if these animals will share the same lifespans as their ancient relatives or if they will be able to survive in the wild, given the changes in their habitats and ecosystems over thousands of years.

Get your game on! Whether you’re into NFL touchdowns, NBA buzzer-beaters, world-class soccer goals, or MLB home runs, our app has it all.

Dive into live coverage, expert insights, breaking news, exclusive videos, and more – plus, stay updated on the latest in current affairs and entertainment. Download now for all-access coverage, right at your fingertips – anytime, anywhere.