Despite a positive performance from The Red Devils at Old Trafford, a goal from Renan Augusto late in the first half was enough for Simeone's side to progress.
Alfredo Relaño reflects on Atlético Madrid's win over Manchester United on Tuesday - a victory that took Los Rojiblancos into the Champions League quarter-finals.
Luis Enrique said after the defeat in Sweden that he was pleased with his team, but when it came to deciding starters this time, he gave the pack a good shuffle.
"Lacking sharpness in one area and solidity in the other, that has been Spain’s problem so far," writes Alfredo Relaño.
Luis Enrique’s team dominated Sweden in their opening game at Euro 2020, but failed to score and allowed Sweden a couple of very dangerous chances.
To be honest, it's not a shock to the system to see Sergio Ramos being omitted from the Spain squad ahead of Euro 2020
REAL VALLADOLID VS ATLÉTICO MADRID
Alfredo Relaño reacts to Atlético Madrid's 2-1 win over Real Sociedad in LaLiga on Wednesday - a result that leaves Diego Simeon's men two victories from the title.
Alfredo Relaño looks back on Atlético Madrid's 1-1 draw with Real Betis on Sunday.
Atlético Madrid were left to rue the vagaries of VAR in the 1-0 defeat against Sevilla as Real Madrid and Barcelona look to capitalize in the title race.
World Cup qualifiers