History-maker Aduriz given the nod
The 35-year-old Athletic Club ace became La Roja's oldest ever goalscorer in their World Cup qualifying win over Macedonia on Saturday night.
Pepe Reina, Ínigo Martínez, César Azpilicueta and Juan Mata also come into the Spain line-up for the clash at Wembley.
Spain XI: Reina; Carvajal, Íñigo Martínez, Nacho, Azpilicueta; Busquets, Koke, Mata; Vitolo, Aduriz and Silva.
Clyne, Lingard and Vardy in for England
Meanwhile, interim England boss Gareth Southgate brings three new faces into the team that began Friday's victory over Scotland.
Nathaniel Clyne, Jesse Lingard and Jamie Vardy replace Kyle Walker, Wayne Rooney and Daniel Sturridge, with Jordan Henderson captaining the hosts in the absence of the injured Rooney.
Follow the coverage match of World Cup 2018 qualifier : Spain vs Israel