Jets - 49ers betting trends: Pick, odds, point spread and over/under prediction | NFL Monday Night Football week 1

In Week 1 of the NFL season, all eyes are on the Monday Night Football clash between the New York Jets and the San Francisco 49ers. The game is packed with storylines, raising two key questions: Will the 49ers suffer a post-Super Bowl slump after last season’s disappointment, and can veteran quarterback Aaron Rodgers stay healthy long enough to make an impact for the Jets?

Jets - 49ers: Pick, odds

The 49ers enter the game as four-and-a-half-point favorites, with the total set at 44. Earlier in the offseason, the 49ers were favored by as much as six-and-a-half points, but injuries and holdouts have since tempered expectations. Key players Deebo Samuel and Trent Williams have recently ended their holdouts. While both are expected to play, questions remain about their game shape and ability to perform at peak levels. The health of Christian McCaffrey is also a concern, as the dynamic running back has a history of injuries and isn’t at full strength heading into the opener.

On the other side, the Jets hope that Rodgers, who tore his Achilles just 94 seconds into last season’s debut, can stay on the field. The veteran QB’s presence could be the missing piece for a Jets roster loaded with talent. The team boasts the league’s No. 5 offensive line, No. 1 defensive line, and top-ranked secondary. If Rodgers can provide average quarterback play, the Jets could win their division and cover the spread in this matchup.

The 49ers’ defense is still strong, with a solid defensive line and a reliable secondary. However, their offensive line may be weak, especially with Williams returning only recently. This could present a challenge for San Francisco in the season opener.

The widely discussed “Super Bowl hangover” doesn’t have a clear answer based on recent history. In the last decade, teams that lost in the Super Bowl have won 6 out of 10 Week 1 games. However, when it comes to the point spread, those teams have only covered 5 out of 24 games since 2020. The 49ers will try to break this trend, but facing a strong Jets team hungry for success, taking the points with New York might be the best bet.

Ultimately, the Jets’ key is simple: Can Aaron Rodgers last more than 94 seconds? If he can, New York might just pull off the upset in this highly anticipated Monday Night Football showdown.