Despite a positive performance from The Red Devils at Old Trafford, a goal from Renan Augusto late in the first half was enough for Simeone's side to progress.
Alfredo Relaño reacts to Barcelona's 4-2 LaLiga win over Atlético Madrid on Sunday - a result that saw the Blaugrana leapfrog Atleti into fourth place.
REAL VALLADOLID VS ATLÉTICO MADRID
After a roller-coaster group stage Karim Benzema guided Real Madrid into the last 16 with LaLiga's other representatives Barcelona, Atlético and Sevilla.
Después del chasco de la Liga de Naciones, toca mirar hacia delante
I'm not sure as to how many consecutive games Harry Kane has failed to score for England, but it had to be yesterday when the Spurs player bucked this trend.