Zinedine Zidane's side slumped to defeat for the second time against their Ukrainian rivals, going down 2-0 after goals from Dentinho and Solomon.
Inter Milan's win over Borussia Mönchengladbach means Real Madrid's fate remains in their hands going into the final round of Champions League Group B games.
Keep up to date with the latest news and reaction related to the political situation in the United States as well as the coronavirus pandemic.
Diego Simeone needs to ensure at least a draw in his final group game to ensure progression in the 2020/21 Champions League.
CHAMPIONS LEAGUE
CHAMPIONS LEAGUE | SHAKHTAR 2 - 0 REAL MADRID
It was yet another game to forget for Zinedine Zidane and Los Blancos as two second half goals from their hosts took qualification out of their hands.
The Real Madrid captain joked he would fancy an Octagon showdown with UFC powerhouse Conor McGregor after a session in the Real Madrid gym.
Victor Oladipo shot down rumours of a trade as he prepares for the 2020-21 season with the Indiana Pacers.
Congress is negotiating a bill to avoid a government shutdown this month and covid-19 relief may be included but a new stimulus check looks unlikely.
Lionel Messi was shown a yellow card for his post-goal tribute to Diego Maradona on Sunday, a decision Ronald Koeman hopes is retrospectively changed.
To combat the injury crisis affecting the squad's central defenders, Barcelona have set their sights on the Atlético centre-back who isn't in Simeone's plans.
The Real Madrid forward limped out of the Alavés game and back in his homeland there have been questions raised about Zidane's management of his injury problems.
Real Madrid boss Zinedine Zidane spoke to the media ahead of Los Blancos' Champions League Group B clash with Shakhtar Donetsk on Tuesday.
Thibaut Courtois made another costly error and Eden Hazard suffered another injury as Real Madrid were deservedly beaten by Deportivo Alavés.
Real Madrid head coach Zinedine Zidane reflected on Saturday's surprise 2-1 home loss to Deportivo Alavés, which came on the back of the Inter win.
REAL MADRID
The Belgian attacker suffered a muscular injury in his right thigh, according to the official medical report published by the LaLiga giants.
The Catalan club will have to pick up the bill for their Argentine's homage to his late compatriot, Diego Armando Maradona, which took place in the win over Osasuna.
During the first half of Barcelona's LaLiga game against Osasuna on Sunday, Lionel Messi went close to recreating the late great Diego Maradona's Hand of God goal.
Barcelona's forward players enjoyed their afternoon as Ronald Koeman's men got back to winning ways in LaLiga with a 4-0 victory over Osasuna.
BARCELONA VS OSASUNA
The dates and venues are set for the quarter-finals of the 2020 CONCACAF Champions League and they will start on 15 December in Orlando, Florida.
Chelsea have the belief they can make a serious bid for the Premier League title this season, according to Blues new boy Hakim Ziyech.
Stéphanie Frappart will make history when she takes charge of Juventus and Dynamo Kyiv's Champions League clash in Turin on Wednesday.
'El Partidazo de COPE', radio show state that the Spanish FA are seriously considering staging the January event in Spain next month.
Italian daily 'Corriere della Sera' maintain that Andrea Pirlo is suffering a communication problem with his team especially in "key and decisive moments".
The Brazilian led Chiangrai United to their first ever win in the AFC Champions League last Friday as the east region competition resumed in Qatar.
CHAMPIONS LEAGUE
The Senate has prevented the Democrats from passing the HEROES Act for months, but wins in the Georgia runoff races would allow Biden to pass a new economic relief package that includes another round of stimulus checks.
A positive coronavirus test means Mercedes will be without Formula One champion Lewis Hamilton for this weekend's Sakhir Grand Prix.
'Iron' Mike Tyson was back in the ring for the first time since 2006 to take on Roy Jones Jr. for a Thanksgiving weekend exhibition bout in California.
BOXING
The world-famous boxer has ink markings across several areas of his anatomy, but many people are asking about the significance of the image of Chinese leader Mao Zedong.
Epic games has announced when the Fortnite Nexus War finale will be and players can join in the live event to save the island from Galactus.
